However, since these antagonists were based on octreotide, they bind to sst2/3/5 receptors and hence were non-selective. binding to a family of five different receptors, sst1-sst5 (ssts) with nanomolar (nM) affinity. The important role of SRIF and its short duration of action due to rapid proteolytic degradation conformational change in Agl8.25; and Grace et al., … Continue reading However, since these antagonists were based on octreotide, they bind to sst2/3/5 receptors and hence were non-selective